V&A Shipping - Southern Region's home-grown Merchant House, owned by the Lodkova-Sud, is Southern's largest merchant house. It's ships travel trades across the region, from Restov to Mivon and has a presence in Tusk, Ringbridge, Wyvern Bridge, Feyfalls andf Jovvox. It carries both trade goods and passengers
DELEM (South) - Owned by House leMaistre, DELEM trades across Southern - with holdings in Tusk, Newgate and Wyvern Bridge, as well as a number of smaller towns. DELEM (their parent house) also has offices in Restov, Brunderton, Sway and New Stetven, and trades all the way from Tusk to New Stetven. Mule and OX-trains carry trade goods and allow other travellers to accompany them, as there is Safety in numbers.
Winter Sun Merchants - Another home-grown Merchant House, WSM concentrates on local trade and is represented in many towns across the region. Its mule and ox trains criss-cross the whole the Southern Region - from Varnhold to Tusk and Wyvern Bridge. It is jointly owned by Swordlord Domitius Aldori-Solanus and Sir Kendrick Winters.
Vallani Trading - Based in Whiterun and Feyfalls, Vallani Trading is a significant presence on the waterborne trade route between Restov and Tusk, carrying both goods and passengers.
Lebeda of Silverhall - the main branch of House Lebeda (one of Brevoy's Great Houses) have recently entered Southern - with jetties and serai at both Wyvern Bridge and Tusk. They appear to be concentrating on this main route across the region, mainly carrying their own goods for transhipment.
House Yitis - An Aldori merchant house, originally from Mivon, who have established a presence in Tusk. They mainly operate a ferry and transport service around Tusk and Tuskwater - and on to Old Keep. However, they have the facilities to trade, securely, with both Mivon (home of their parent house) and Restov.
Roth Coaches provide fast, land based, travel between Tusk, Wyvern Bridge and Newgate - stopping off at all the other towns on the way.